JOURNAL OF MEDICINAL CHEMISTRY（药物化学杂志）影响因子_期刊投稿发表

期刊简介

The Journal of Medicinal Chemistry发表分子结构与生物活性或作用模式之间关系的相关研究。The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.Some specific areas that are appropriate include the following:Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《药物化学杂志》发表的研究有助于理解分子结构和生物活性或作用模式之间的关系。一些适合的特定领域包括：* 新型生物活性化合物、诊断剂或用作药理学工具的标记配体的设计、合成和生物学评价。* 对报告系列进行分子修饰，从而显著改善对其构效关系（SAR）的理解。对现有系列的常规扩展，如果未使用新的化学或生物学方法，或未显著增加对系列SAR的基本理解，则通常不接受发表。* 结构生物学研究（X射线、NMR等）目的是研究生物活性化合物作用中的分子识别过程。* 分子生物学研究（如：定点诱变），这导致对分子识别的更好理解。* 计算研究，为当前普遍感兴趣的化合物系列的SAR提供新的见解，或对随后推进药物化学知识的其他可用数据进行分析。* 实质上新颖的计算化学方法，具有经证实的用于生物活性分子的鉴定、优化或靶相互作用分析的价值。* 分子结构对生物活性化合物的分布、药代动力学和代谢转化的影响。这可能包括新型前药的设计、合成和评价。* 广泛应用于药物化学的新方法，但前提是该方法已在相关分子上进行了测试。

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